Our Team

Current members

Inge R. Holtman

Inge R. Holtman

Assistant Professor – Rosalind Franklin Junior Group Leader

In 2020, Dr. Holtman successfully pursued a Rosalind Franklin Fellowship that enabled her to become a junior group leader in the section of Molecular Neurobiology. Here she continues to study the effect of natural genetic variation on susceptibility to brain diseases. In collaboration with the Netherlands Brain Bank, she established the Netherlands Neurogenomics Database, supported by the Stichting Vrienden van het Herseninstituut.

Alejandro Marmolejo Garza

Postdoctoral Fellow

I am a Medical Doctor with a master’s in Medical and Pharmaceutical Drug Innovation with specialization in metabolism. My PhD research focused on mitochondrial involvement in Alzheimer’s disease using iPSC-derived brain organoids and microglia-like cells. As a postdoctoral fellow, I focus on developing brain organoid models that recapitulate psychiatric disease.

Alejandro Marmolejo Garza
Ekaterina Dagkesamanskaia

Ekaterina Dagkesamanskaia

PhD student

My research focuses on deciphering the heterogeneity of brain disorders using bioinformatics by integrating neuropathology, clinical summaries, and genetic information.

Nienke Mekkes

PhD student

My project aims to better understand brain disorders through a cross-diagnostic approach integrating clinical, neuropathological, and multi-omics data.

Nienke Mekkes
Shivam Kumar

Shivam Kumar

Postdoctoral Fellow

Shivam is a machine learning researcher with a background in biomedical imaging and deep learning. His work focuses on leveraging pathological imaging data to predict clinical traits and uncover genetic profiles.

Eric Hoekstra

Technician – Bioinformatician

Eric joined the lab in 2021 and focuses on building and maintaining the Netherlands Neurogenomics Database, data infrastructure, and computational pipelines.

Eric Hoekstra
Ruhi Soni

Ruhi Soni

Research Analyst

Ruhi joined the Holtman lab in 2025 after completing an MSc in Bioinformatics and Systems Biology. She focuses on biological signatures underlying psychiatric disorders.

Former members

  • Tommaso Fortunato Asquini
  • Ekaterina Dagkesamanskaia
  • Maaike Brummer
  • Gwenny Leistra
  • Sander Bouwman
  • Bart Engels
  • Alyse de Boer
  • Henrike Vaartstra